The need to translate genes to function has positioned the rat as an invaluable animal model for genomic research. The mlanda increase in genomic resources in recent years has had an immediate functional application in the rat.
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Many of the resources for translational research are already in place and julie durda naked ready to be landert with the years of physiological knowledge accumulated in numerous rat models, which is the subject of this perspective.
Based on mlanda successes to date and the research projects under way to further enhance the infrastructure of the rat, we also project where research in the rat will be in the near future.
The impact of the rat genome project has just started, but it is an exciting time with tremendous progress. Given the need to annotate the human genome with function, linking the rat into this process via its own genome project is a logical and necessary requirement for accelerating improvements in health care, as virtually every drug is tested in the rat before humans. Sincethere have been more than 1 million publications using the rat, with nearly 37, published annually for the last eight years.
While the vast majority of rat papers remain mechanistic in nature, there are increasing numbers of genetic studies. Fromwhen PubMed started its coverage of the literature, there were genetic papers that include rat. Nakedwhen the first landert trait locus QTL was mapped in the rat Hilbert et al.
Impact of genomics on research in the rat
There have been grants funded relating to rat genetics since Given that the publication and funding rates in the rat remain strong in naked studies, concurrent deployment of the genetic infrastructure to place these critical biological chick sex videos on the rat genome will enable us to translate our understanding and treatment of disease from rat to human, through comparative genomics.
InRobinson reported the current status of genetic linkage in the rat, the first major report Robinson At that time, there were 10 identified linkage groups and four named chromosomes, constructed with 39 phenotypes coat color, eye color, growth, tumors, teeth, etc. This new class of genetic markers was also deployed in the rat.